General Concepts 6 min read
Iodination
Organoiodine compounds are uncommon in nature and not very frequently found in pharmaceuticals and agrochemicals (cf.Fig. 2). Until 2014, 184…
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Bromination
Bromination of organic compounds is one of the most important transformations in organic synthesis. In addition to the many uses…
General Concepts 4 min read
Chlorination
The importance of chlorinated organic compounds in the field of agrochemicals and pharmaceuticals is comparable to that for organofluorines regarding…
General Concepts 5 min read
Fluorination
Organofluoride compounds have become one of the most important and common class of substances among pharmaceuticals and agrochemicals (cf.Fig. 2b).22Decoration…
General Concepts 5 min read
Halogenation of organic compounds using continuous flow and microreactor technology
Abstract The halogenation of organic substrates is one the most important transformations in organic synthesis. The most straightforward, inexpensive and…
General Concepts 5 min read
Continuous handling of reactions forming solids
We selected two reactions to assess the ability of the CSTR cascade to handle the formation of solids: (i) reaction…
General Concepts 6 min read
General procedure for solid-forming reactions in the CSTR cascade
The scheme of the setup for continuous handling of solid-forming reactions in the CSTR cascade is shown in Fig. S2…
General Concepts 2 min read
Residence time distribution (RTD) characterization
The RTD profiles of the CSTR cascade were obtained using the pulse injection method (Fig. 2). The carrier phase was…
General Concepts 2 min read
Experimental section
Materials Reagents and chemicals used in this work, including methylene blue, isoprene, maleic acid anhydride, dimethylformamide (DMF), glyoxal, cyclohexylamine, ethanol,…
General Concepts 4 min read
A miniature CSTR cascade for continuous flow of reactions containing solids
Abstract Continuous handling of solids creates challenges for realizing continuous production of pharmaceuticals and fine chemicals. We present a new…
General Concepts 4 min read
Chemistry
For the difluoromethylation reaction, the inlets A, B and D were attached with standard connectors to three syringe pumps (Asia…
General Concepts 4 min read
Reactor printing and characterization
For the SLM process, the 3D CAD model is dissected by the process software into a series of cross-sectional slices.…