Kinetic Isotope Effects
The kinetic isotope effect (KIE) is a phenomenon associated with isotopically substituted molecules exhibiting…
Kinetic Versus Thermodynamic Products
Kinetic products form the fastest. They usually occur at or below 0°C.…
The Principle of Microscopic Reversibility
The principle of microscopic reversibility applies to any molecular process; it is…
Definition of a Reaction Intermediate
What exactly is a reaction intermediate? A reaction intermediate is formed from the reactants…
Transition state
The transition state of a chemical reaction is a particular configuration along the reaction coordinate. It is…
Ester Enolates
we introduced the enolates of aldehydes and ketones (review) and looked at…
Acid-Catalyzed Ester Hydrolysis
Water the Destroyer Imagine that water, the stuff you drink everyday, is…
Reaction with Primary Amines to form Imines
The reaction of aldehydes and ketones with ammonia or 1º-amines forms imine derivatives, also…
Nomenclature of Aldehydes & Ketones
Aldehydes and ketones contain the carbonyl group. Aldehydes are considered the most…
Acetal Formation
Introduction It has been demonstrated that water adds rapidly to the carbonyl…


